Best Acetyl Tetrapeptide-40 (≥98%) Cosmetic Grade for Eye Contour Care Supplier, Companies

1 / 1

Best Acetyl Tetrapeptide-40 (≥98%) Cosmetic Grade for Eye Contour Care Supplier, Companies

Products Name	Â Acetyl Tetrapeptide-40
CAS No	Â 1472633-28-5
INCI Name	Â Acetyl Tetrapeptide-40
Specification	Â â‰¥98% (HPLC)
Molecular Weight	Â 461.5 g/molÂ
Chemical Formula	Â Câ‚‚â‚Hâ‚ƒâ‚Nâ‚‡Oâ‚† (free acid)
Appearance	Â White to off-white powder
Solubility	Â Soluble in water

Send Inquiry

Product Description

1. Mechanism of Action (MOA)

Acetyl Tetrapeptide-40 is a biomimetic peptide specifically designed to combat the signs of aging and fatigue in the eye contour area. Its mechanism is multi-faceted, targeting both cellular energy metabolism and the dermal-epidermal junction (DEJ):

Cellular Energy Activation:
The peptide acts as a potent activator of cytochrome c oxidase (Complex IV), a key enzyme in the mitochondrial electron transport chain. By enhancing mitochondrial function, it boosts ATP production in skin cells, revitalizing tired-looking skin.

Strengthening the Dermal-Epidermal Junction (DEJ):
It stimulates the synthesis of Collagen Type IV, VII and Laminin-5. A cohesive DEJ improves skin firmness and reduces sagging, which contributes to under-eye bags.

Anti-Glycation Activity:
Protects proteins like collagen from glycation, preventing stiffness, yellowing, and loss of skin function.

2. In Vitro Efficacy Data

Mitochondrial Activity: Demonstrated a significant, dose-dependent increase in ATP production.
DEJ Protein Synthesis: Confirmed upregulation of Collagen IV, VII, and Laminin-5.
Anti-Glycation: Inhibits the formation of AGEs to maintain collagen flexibility.

3. Clinical Results

A 56-day, double-blind study (5 ppm Acetyl Tetrapeptide-40 twice daily) showed:

Reduction in Puffiness: Improved smoothness and firmness of the under-eye area.
Diminished Dark Circles: Visible reduction in bluish/dark appearance.
Enhanced Radiance: Over 80% of subjects perceived eyes looking more radiant and awake.

Safety & Compatibility

Safety Profile

Excellent topical safety. Non-irritating and non-sensitizing. Proven safe for the delicate eye area.

Biocompatibility

As a biomimetic peptide, it is exceptionally well-tolerated by human skin.

Formulation Compatibility

Highly soluble in aqueous phases. Stable across pH 4.0-8.0. Compatible with antioxidants and hyaluronic acid.

Recommended Usage & Dosage

Recommended Concentration: 2 to 10 ppm (0.0002% - 0.001%)

Typical Use Level: 5 ppm (0.0005%) is clinically proven.

Applications: Eye creams, gels, serums, patches, and anti-fatigue facial products.

Summary & Key Selling Points

Energetic Revival: Boosts mitochondrial ATP to combat fatigue.

Structural Reinforcement: Strengthens DEJ for improved firmness.

Multi-Faceted: Targets puffiness and dark circles simultaneously.

Clinically Proven: Visible results in radiance and skin smoothing.

High Potency: Effective at very low ppm concentrations.

Storage: Room temperature, dry place.

Animal Testing: Not animal tested.

Vegan: No animal-derived components.

GMO: No data available.

Frequently Asked Questions

Q: What is the primary benefit of Acetyl Tetrapeptide-40?

A: It is primarily used to revitalize the eye area by boosting cellular energy (ATP) and strengthening the skin structure to reduce puffiness and dark circles.

Q: How soon can clinical results be observed?

A: In clinical studies, significant improvements in skin firmness and radiance were measured over a 56-day period with twice-daily application.

Q: What is the recommended dosage for cosmetic formulations?

A: The standard and clinically effective concentration is 5 ppm (0.0005%), though it can be used between 2 to 10 ppm.

Q: Is Acetyl Tetrapeptide-40 compatible with other active ingredients?

A: Yes, it is highly soluble and compatible with common ingredients like hyaluronic acid, antioxidants, and other peptides.

Q: Is this product suitable for vegan formulations?

A: Yes, it is a biomimetic peptide and does not contain any animal-derived components.

Q: How should the peptide be stored?

A: It should be stored in a closed container in a dry place at room temperature to maintain its stability.