Best Copper Tripeptide-1 Wound Healing & Anti-Aging Peptide Suppliers, Factory

Products Name Copper Tripeptide-1
CAS No 89030-95-5
INCI Name Copper Tripeptide-1
Specification ≥98% (HPLC)
Molecular Weight  340.8 g/mol (for Cu(II)-GHK complex)
Chemical Formula C₁₄H₂₂CuN₆O₄
Appearance  Blue to blue-violet powder
Solubility Soluble in water and aqueous solutions

Product Description

Product Description

Copper Tripeptide-1 Mechanism

Mechanism of Action (MOA)

Copper Tripeptide-1 (GHK-Cu) is a naturally occurring copper-binding peptide that plays a fundamental role in tissue repair and regeneration through multiple pathways:

Extracellular Matrix Remodeling:

  • Upregulates synthesis of key structural proteins including collagen I, III, IV, elastin, and glycosaminoglycans.
  • Modulates matrix metalloproteinases (MMPs) to promote balanced tissue remodeling - inhibiting MMP-1 while activating MMP-2 for organized collagen deposition.

Stem Cell Activation & Cellular Communication:

  • Attracts immune cells and fibroblasts to wound sites, enhancing tissue repair.
  • Promotes the differentiation of mesenchymal stem cells and stimulates angiogenesis.

Anti-Inflammatory & Antioxidant Effects:

  • Suppresses reactive oxygen species and reduces inflammatory cytokines like TNF-α.
  • Upregulates antioxidant enzymes including superoxide dismutase and metallothionein.

In Vitro Efficacy & Clinical Results

In Vitro Efficacy Data

  • Collagen Synthesis: 2.8-fold increase in collagen production in human fibroblast cultures at 1 μM.
  • Gene Expression: Upregulation of 31 genes involved in tissue repair and anti-oxidation.
  • MMP Modulation: 60% inhibition of MMP-1 (collagenase) while increasing MMP-2 (gelatinase) activity.
  • Cell Migration: 3.5-fold enhancement of fibroblast migration in scratch wound assays.

Clinical Trial Results

12-week study on 60 volunteers (40-65 years) using 5 ppm Copper Tripeptide-1:

  • Wrinkle Reduction: 35% improvement in fine lines.
  • Firmness & Elasticity: 18% increase in cutometer measurements.
  • Skin Texture: 42% improvement in smoothness.
  • Barrier Function: 25% reduction in TEWL and enhanced hydration.

Safety & Compatibility

Safety Icon

Safety

Excellent safety profile with over 30 years of clinical use. Non-irritating, non-sensitizing, suitable for sensitive skin.

Compatibility Icon

Compatibility

Stable in pH 5.0-7.5. Avoid strong chelating agents (EDTA), high metal concentrations, and strong reducing agents.

Tips Icon

Formulation Tips

Protect from light and oxidation. Ideal for aqueous systems and emulsions.

Recommended Usage & Dosage

Usage Guide

Concentration: 1-10 ppm (0.0001%-0.001%) in final formulations.

Optimal Dose: 5 ppm for clinically proven regenerative effects.

Applicable Products:

  • Anti-aging serums and creams
  • Wound healing formulations
  • Post-procedure treatments
  • Hair growth products
  • Scar reduction formulations

Key Selling Points

Regeneration
Clinical Data
Biomimetic
Storage
Storage: Store in a closed container at a dry place at room temperature.
Testing
Animal Testing: Not animal tested.
Vegan
Vegan: Does not contain animal-derived components.
GMO
GMO: No GMO data available.

Frequently Asked Questions

Q1: What is the optimal concentration of Copper Tripeptide-1 for anti-aging?

A: The clinically proven optimal dose is 5 ppm (0.0005%), although it is effective within a range of 1-10 ppm.

Q2: Can Copper Tripeptide-1 be used on sensitive skin?

A: Yes, it has an excellent safety profile with over 30 years of clinical history. It is non-irritating and suitable for sensitive skin types.

Q3: What ingredients should be avoided when formulating with GHK-Cu?

A: Avoid using strong chelating agents like EDTA, high concentrations of other metals, and strong reducing agents, as these can affect the stability of the copper peptide.

Q4: What are the primary benefits for skin texture?

A: Clinical trials show up to a 42% improvement in skin smoothness and roughness, alongside significant reductions in fine lines and wrinkles.

Q5: Is this product suitable for vegan formulations?

A: Yes, the product does not contain any animal-derived components and is considered vegan-friendly.

Q6: How should the final formulation be stored?

A: It is recommended to protect the final products from light and oxidation, ideally in a closed container in a cool, dry place.

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