Custom Acetyl Tetrapeptide-2 The Neuro-Soothing Peptide for Redness & Rosacea Manufacturer, Manufacturers

Products Name  Acetyl Tetrapeptide-2
CAS No  1239011-60-9
INCI Name  Acetyl Tetrapeptide-2
Specification   ≥98% (HPLC)
Molecular Weight  487.5 g/mol
Chemical Formula   C₂₂H₃₇N₇O₇
Appearance  White to off-white crystalline powder
Solubility  Soluble in water and glycerin

Product Description

Product Description
Product Description

1. Mechanism of Action (MOA)

Acetyl Tetrapeptide-2 is a biomimetic peptide specifically designed to target and mitigate neurogenic inflammation, a key driver of facial redness and sensitivity, particularly in conditions like rosacea.

  • Targeted Inhibition of Substance P Release: Modulates sensory neurons to reduce Substance P, a neuropeptide triggering inflammation and vasodilation.
  • Interruption of Neurogenic Inflammation: Breaks the cycle of nerve-induced flare-ups and visible redness.
  • Improvement of Skin Barrier Function: Calms nerves to support the repair and strengthening of the skin's natural protective barrier.
In Vitro Efficacy Data
Based on human keratinocyte cultures and neuronal cell models, findings include:
Dose-Dependent Reduction
Inhibits Substance P release from sensory neurons triggered by stimuli.
Downregulation of Mediators
Marked decrease in pro-inflammatory cytokines like IL-8.
Barrier Gene Expression
Upregulation of genes involved in forming skin tight junctions.
Clinical Results

Human clinical studies on Rosacea & Redness-Prone Skin (4-8 weeks) showed:

Instrumental Analysis:
  • Significant reduction in redness intensity and area.
  • Decrease in flushing episodes frequency.
  • Improved overall skin comfort.
Self-Assessment:

Over 80% of participants agreed their skin felt "more calm," "less reactive," and "soothed" after continued use.

Safety & Compatibility
Safety Profile
Compatibility

Safety Profile

Non-irritating and non-sensitizing. Specifically designed for fragile, reactive skin and suitable for long-term use.

Compatibility

Synergistic Combinations:
Works effectively with Niacinamide (barrier strength), Centella Asiatica (anti-inflammatory), and Ceramides (lipid repair).

Recommended Usage & Formulation

Recommended Concentration: 2 - 6 ppm (0.0002% - 0.0006%) in the final product. Effective at very low concentrations.

Applications:

  • Redness Relief & Anti-Redness Serums
  • Daily Moisturizers for Rosacea-Prone Skin
  • Soothing Creams & Masks
  • Post-Procedure Recovery (Lasers/Peels)
Key Selling Points Summary
Root Cause Targets Root Cause
Inhibits Substance P beyond surface-level soothing.
Proven Clinically Proven
Demonstrated efficacy in reducing facial redness.
Calm Rapid & Lasting Calm
Immediate soothing and long-term reactivity management.
Safe Exceptionally Safe
Suited for the most fragile and intolerant skin types.
Barrier Barrier-Supportive
Aids repair by calming underlying neural inflammation.
Marketing Marketing Synergy
Aligns with the "neurocosmetics" trend.
Storage

Storage
Dry place, Room temperature

Animal Testing

Animal Testing
Not animal tested

Vegan

Vegan
No animal-derived components

GMO

GMO
No data available

Frequently Asked Questions (FAQ)
Q: What is the main benefit of Acetyl Tetrapeptide-2?

A: It acts as a "neuro-soother" that specifically targets neurological signals causing redness and irritation, effectively managing reactive and rosacea-prone skin.

Q: How does it work at a cellular level?

A: It inhibits the release of Substance P from sensory neurons, which reduces neurogenic inflammation and prevents the widening of blood vessels.

Q: What is the recommended dosage for skincare formulations?

A: It is effective at very low concentrations, with a recommended usage of 2 to 6 ppm (0.0002% - 0.0006%).

Q: Can it be used in post-procedure skincare?

A: Yes, it is ideal for post-procedure recovery serums to minimize redness and discomfort following treatments like chemical peels or lasers.

Q: Is this ingredient suitable for long-term use?

A: Absolutely. It is non-irritating, non-sensitizing, and highly targeted, making it safe for daily maintenance of fragile skin.

Q: Is it compatible with other common anti-aging ingredients?

A: Yes, it shows excellent synergy with Niacinamide, Ceramides, and botanical extracts like Centella Asiatica for comprehensive barrier support.

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