Aogebio Cosmetic
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Palmitoyl Tripeptide-3 is a biomimetic signal peptide designed to specifically target and strengthen the skin's barrier function at a fundamental level. Its mechanism is distinct from soothing or anti-aging peptides.
Its primary target is the upregulation of key structural proteins that form "Tight Junctions" (TJs), particularly Claudin-1. Tight Junctions are the seal between skin cells in the stratum corneum, acting as a primary gatekeeper against external aggressors and preventing water loss.
By stimulating the synthesis of Claudin-1, Palmitoyl Tripeptide-3 effectively "cements" the skin cells together, leading to a denser, more cohesive, and less permeable barrier.
Multi-Faceted Barrier Support: This action complements the role of lipids (the "mortar") and other structural proteins like filaggrin, resulting in a comprehensive reinforcement of the skin's defense system. In summary, it acts as a biological signal to "instruct" skin cells to build stronger and tighter connections.
Tested on human keratinocyte cultures (HaCaT cells) and 3D reconstructed human epidermis models.
TEWL Measurement: A statistically significant reduction in Transepidermal Water Loss was observed with 2-5 ppm concentration, indicating a more effective barrier.
SLS Challenge Test: Areas pre-treated with the peptide showed significantly less erythema (redness) and irritation compared to untreated areas after exposure to Sodium Lauryl Sulfate.
Non-irritating, non-sensitizing, and highly biocompatible. Suitable for all skin types, especially those with impaired or sensitive barriers.
Synergistic Combinations: Works excellently with Ceramides, Cholesterol, and Fatty Acids. Also pairs well with soothing agents like Niacinamide or Bisabolol.
Recommended Concentration: 2 - 10 ppm (0.0002% - 0.001%). Highly effective at very low concentrations.
Storage: Dry place, Room Temperature
Not Animal Tested
Vegan Friendly
GMO Free (No Data)
