OEM What Does Dipeptide-6 Do in Cosmetics? Manufacturers, Companies

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OEM What Does Dipeptide-6 Do in Cosmetics? Manufacturers, Companies

Products Name	Dipeptide-6Â Â
CAS No	18684-24-7
INCI Name	Dipeptide-6
Molecular Weight	217.22 g/mol
Chemical Formula	Câ‚ˆHâ‚â‚…Nâ‚ƒOâ‚„
Appearance	White to off-white crystalline powder
Solubility	Freely soluble in water

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Product Description

1. MOA - Mechanism of Action

Dipeptide-6 (Alanyl-Glutamine) is a stabilized and highly bioavailable precursor to the amino acid L-Glutamine. Its primary mechanism focuses on cellular energy metabolism and hydration:

Precursor to L-Glutamine: Efficiently cleaved by skin enzymes to release L-Alanine and L-Glutamine.
Fuel for Proliferating Cells: Supports fibroblasts and keratinocytes as a primary energy source for collagen and elastin production.
Osmolyte Function: Regulates cellular volume and influences Aquaporin-3 (AQP3) for water transport.
Antioxidant Support: Precursor to glutathione, protecting cells from oxidative stress.

Summary: Dipeptide-6 → Delivers L-Glutamine → Fuels Cellular Energy → Enhances AQP3-mediated Hydration → Supports Skin Repair.

Efficacy & Clinical Results

In Vitro Data

ATP Boost: Increases intracellular energy levels in fibroblasts.
AQP3 Up-regulation: Significantly enhances water channel expression.
Barrier Improvement: Marked increase in skin hydration and barrier function.

Clinical Results (2% Conc.)

Wrinkle Reduction: Significant decrease in depth and volume within 28-56 days.
Hydration Boost: Over 30% increase in skin hydration levels.
Firmness: Statistically significant improvement in skin elasticity.
Radiance: Visible improvement in smoothness and plumpness.

Safety & Compatibility

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Safety Profile

Non-irritating and non-sensitizing. Composed of skin-identical amino acids, making it ideal for sensitive skin and excellent biocompatibility.

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Formulation Guidelines

Water-soluble and stable within pH 4.0 - 8.0. Should be incorporated at temperatures below 45°C to ensure peptide stability.

Usage & Formulation

Recommended Concentration: 1.0% - 5.0%

Anti-aging Serums and Ampoules
Moisturizing Creams and Lotions
Hydrating & Plumping Sheet Masks

Eye Creams for fine lines
Barrier Repair Formulations

Key Selling Points

Cellular Energy Booster: Directly fuels fibroblasts to enhance regeneration.

Deep Hydration Technology: Up-regulates AQP3 to plump skin from within.

Safe & Skin-Identical: Natural amino acid composition with high safety profile.

Storage: Dry place at room temperature.

Animal Testing: Not animal tested.

Vegan: No animal-derived components.

Frequently Asked Questions

❓ What is Dipeptide-6?

Dipeptide-6, also known as Alanyl-Glutamine, is a highly stable peptide that serves as a precursor to L-Glutamine, an essential energy source for skin cells.

❓ How does it improve skin hydration?

It functions by up-regulating Aquaporin-3 (AQP3) channels, which facilitate the transport of water and glycerol into skin cells, providing deep and long-lasting hydration.

❓ Is Dipeptide-6 effective against wrinkles?

Yes, clinical studies have shown that a 2% concentration of Dipeptide-6 significantly reduces wrinkle depth and volume while improving overall skin firmness.

❓ What is the recommended dosage for skincare products?

The typical recommended concentration is between 1.0% and 5.0% in the final cosmetic formulation.

❓ Is this ingredient suitable for sensitive skin?

Absolutely. Dipeptide-6 is composed of natural, skin-identical amino acids and is proven to be non-irritating and non-sensitizing.

❓ What are the formulation requirements?

It is water-soluble, stable in a pH range of 4.0 to 8.0, and should be added to the formulation at temperatures below 45°C.