High-Quality Why Palmitoyl Tripeptide-38 is Becoming Essential in Advanced Anti-Aging Formulations Factory, Exporter

Products Name  Palmitoyl Tripeptide-38
CAS No  1447824-23-8
INCI Name  Palmitoyl Tripeptide-38
Specification  ≥95% (HPLC)
Molecular Weight  610.8 g/mol
Chemical Formula  C₃₃H₆₂N₄O₆
Appearance  White to off-white fine powder
Solubility  Soluble in polar solvents (ethanol, propylene glycol), dispersible in water.

Product Description

Product Description
Palmitoyl Tripeptide-38 Action
1. Mechanism of Action (MOA)

Palmitoyl Tripeptide-38 is a biomimetic peptide specifically engineered to target and reinforce the dermal-epidermal junction (DEJ), a critical structure for maintaining skin's youthful architecture and firmness.

  • Reinforcement of the Dermal-Epidermal Junction (DEJ): The peptide acts as a signal molecule to stimulate the synthesis and organization of key structural components at the DEJ, particularly Collagen Type IV, Collagen Type VII, and Laminin V.
  • Stimulation of Dermal Matrix Components: It promotes the production of Collagen Type I and III in the dermis, enhancing skin density and elasticity.
  • Biomimetic Signaling: Designed to mimic natural repair processes, communicating with skin cells to upregulate youth-associated proteins.
2. In Vitro Efficacy Data

Increased DEJ Protein Synthesis: Significantly increased production of Collagen IV (by over 200%), Collagen VII, and Laminin V.

Enhanced Dermal Collagen: Marked upregulation in the synthesis of Collagen I and III by human dermal fibroblasts.

Gene Expression: Positively modulates skin cell gene expression towards a matrix-producing state.

3. Clinical Results

Clinical studies confirm significant anti-aging benefits after 12 weeks of use (3 ppm twice daily):

Firmness: Statistically significant improvement in skin firmness and elasticity.
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Wrinkle Reduction: Reduction in depth and volume of wrinkles, especially crow's feet.
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Lifting Effect: Visible reduction in sagging and improved facial contouring.
Safety & Compatibility
Safety Profile
Compatibility
Safety Profile

Palmitoyl Tripeptide-38 is well-tolerated and non-irritating when applied topically at recommended concentrations. It is suitable for all skin types, including sensitive skin.

Compatibility & Stability

Synergistic Combinations: Works well with other peptides (e.g., Matrixyl 3000), Hyaluronic Acid, Niacinamide, and Antioxidants (Vitamin C, E).

Formulation Stability: Stable under standard cosmetic pH conditions (pH 4.0 - 7.0) and typical processing temperatures.

Usage & Formulations
Recommended Usage Level: 2 - 5 ppm (0.0002% - 0.0005%)

A highly potent ingredient effective at very low concentrations.

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Suitable Products: Anti-Aging & Firming Serums, Day/Night Creams, Eye Contour Creams, and Concentrated Ampoules.